By Shein-Chung Chow,Mark Chang
With new statistical and clinical concerns bobbing up in adaptive medical trial layout, together with the U.S. FDA’s contemporary draft information, a brand new variation of 1 of the 1st books at the subject is required. Adaptive layout tools in scientific Trials, moment Edition displays fresh advancements and regulatory positions at the use of adaptive designs in medical trials. It unifies the immense and regularly becoming literature and learn actions on regulatory requisites, medical and functional matters, and statistical methodology.
New to the second one Edition
Along with revisions through the textual content, this version considerably updates the chapters on protocol modification and medical trial simulation to include the most recent adjustments. it's also 5 completely new chapters on two-stage adaptive layout, biomarker adaptive trials, aim medical trials, pattern dimension and gear estimation, and regulatory perspectives.
Following within the culture of its acclaimed predecessor, this moment version keeps to supply an updated source for scientific scientists and researchers in academia, regulatory enterprises, and the pharmaceutical undefined. Written in an intuitive kind at a easy mathematical and statistical point, the booklet continues its sensible technique with an emphasis on innovations through a number of examples and illustrations.
Read Online or Download Adaptive Design Methods in Clinical Trials, Second Edition (Chapman & Hall/CRC Biostatistics Series) PDF
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